Many　natural　products　have　remarkable　biological　functions　due　to　their　fascinating　molecular　architectures.　Despite　many　advances　in　synthetic　method　development,　the　efficient　synthesis　of　highly　functionalized　and　structurally　intricate　natural　products　to　meet　the　demand　for　biological　investigations　remains　a　daunting　challenge.　Molecular　editing　encompassing　insertion,　deletion,　or　exchange　of　atoms　of　highly　functionalized　compounds　has　emerged　as　a　hotspot　in　new　method　development　and　has　been　applied　in　complex　natural　product　synthesis.　In　this　highlight,　the　latest　developments　in　molecular　editing　in　natural　product　synthesis　are　discussed.　©　2022　the　Partner　Organisations.