Systematic　interrogation　of　correlative　signaling　components　in　their　native　environment　is　of　great　interest　for　dissecting　sophisticated　cellular　signaling.　However,　it　remains　a　challenge　because　of　the　lack　of　versatile　and　effective　approaches.　Herein,　we　propose　a　cell　membrane-anchored　DNA　multitasking　processor　acting　as　a　＇traffic　light＇　for　integrated　analyses　of　cellular　signal　transduction.　Enhanced　and　controllable　inhibition　of　c-Met　signaling　was　achieved　by　membrane-anchoring　of　DNA　processors.　Moreover,　the　multitasking　capability　of　the　DNA　processor　allowed　the　monitoring　of　correlative　VEGF　secretion　induced　by　c-Met　activity　regulation　directly.　By　exploiting　versatile　aptameric　nucleic　acids,　this　modular　designed　DNA　multitasking　processor　dissected　how　cell　surface　receptors　coordinated　with　related　components　in　live　cells　systematically.　Therefore,　it　provides　a　powerful　chemical　tool　for　both　fundamental　cell　biology　research　and　precision　medicine　applications.　©　2022　Wiley-VCH　GmbH