To　investigate　the　effect　of　nano　carbon-fiber-reinforced　polymer　(nano　CFRP)　on　retrofitting　reinforced　concrete　(RC)　structures,　this　article　presented　the　progressive　collapse　performance　of　two　half-scale　four-bay　RC　frames　including　one　control　specimen　S1　and　specimen　S2　with　nano　CFRP　retrofitting　beam　ends.　The　progressive　collapse　performance　was　discussed　by　comparing　crack　patterns,　failure　mode,　load-displacement　curves,　horizontal　displacement,　strains,　and　rotational　and　energy　dissipation　capacity.　The　test　results　demonstrated　that　nano　CFRP　did　not　change　the　ductile　beam-hinge　failure　mode,　but　improved　the　load-bearing　capacity　and　ductility　efficiently,　and　postpone　shear　failure　of　the　joint　core　region　obviously.　Due　to　the　insufficient　development　of　plastic　hinges　limited　by　nano　CFRP,　S2　failed　to　enter　catenary　action,　which　revealed　its　own　defects　in　anti-progressive　collapse.　It　was　shown　that　the　retrofitting　strategy　using　nano　CFRP　can　substantially　improve　the　mechanical　characteristics　and　implement　the　strong　column-weak　beam　failure　mode.　©　2022　Weihong　Chen　et　al.,　published　by　De　Gruyter.