High　mechanical　stability　during　cyclic　tensile　loading–unloading　courses　is　critical　for　the　actual　applications　of　hydrogels　in　the　wearable　electronic　equipment　and　human–machine　interfaces.　However,　the　conventional　hydrogels　prominently　confront　poor　mechanical　performances　and　are　subjected　to　fatigue　fracture　under　continuous　loading–unloading　cycles.　Herein,　a　facile　strategy　is　proposed　to　prepare　a　hybrid　physically　and　chemically　crosslinked　double　network　organohydrogel.　The　gelatin　forms　the　physically　cross-linked　network　through　sol–gel　transition　and　salting-out　effect.　The　poly(acrylamide)　(PAM)　chains　construct　the　chemically　cross-linked　network.　The　prepared　gelatin/PAM/DMSO/Na2SO4　(GPDN)　organohydrogels　displayed　splendid　mechanical　properties.　Furthermore,　GPDN　organohydrogels　showed　the　high　anti-fatigue　property　over　1000　tensile　cycles　at　the　fixed　strain　of　300%　without　obvious　plastic　deformation.　In　particular,　the　GPDN　organohydrogel　displayed　high　ionic　conductivity　and　could　be　used　as　the　strain　sensor　to　detect　multiple　external　stimuli　(tension,　compression,　and　bending)　with　high　sensitivity　(gauge　factor　of　7.13)　and　favorable　cyclic　stability.　©　2022　Elsevier　Ltd