This　study　investigated　the　effects　of　microalgae-bacteria　consortia　(MBC)　(Chlorella　pyrenoidosa-activated　sludge　(AS))　treating　swine　wastewater　with　low　C/N　ratios.　After　co-culture,　the　removal　rates　of　NH4+-N　and　PO43--P　increased　by　53.84%　and　43.52%.　Furthermore,　the　sulfamethoxazole　(SMX)　degradation　rates　in　MBC　were　slightly　higher　than　in　the　activated　sludge　process.　Interestingly,　the　absolute　abundance　of　antibiotic　resistance　genes　(ARGs)　in　effluent　from　MBC　is　relatively　less　than　in　the　AS　process.　C.　pyrenoidosa　has　a　negative　zeta　potential　that　allows　bacteria　to　adhere　to　its　surface.　The　concentrations　of　carbohydrates　and　proteins　in　extracellular　polymeric　substance　(EPS)　of　MBC　dramatically　increased　compared　with　the　AS　process.　At　the　phylum　level,　Proteobacteria,　Bacteroidota,　and　Cyanobacteria　were　the　main　bacteria,　while　Ascomycota　and　Basidiomycota　were　the　primary　fungi　in　MBC.　Overall,　those　findings　lead　to　a　better　understanding　of　the　swine　wastewater　containing　antibiotic　treatment　by　MBC.　©　2022