Separation　of　ethylene　(C2H4)　from　ethane　(C2H6)　through　one　step　is　desirable　but　challenging　in　view　of　their　similar　sizes　and　physical　properties.　Introduction　of　pore　partition　agents　into　metal-organic　frameworks　(MOFs)　endows　materials　with　multivariate　porous　environments　for　gas　adsorption　and　separation.　Here,　we　report　a　novel　microporous　boron　imidazolate　framework　(BIF-108-Zn)　that　integrates　both　organic　ligands　and　extra-framework　species　as　pore　partition　agents　to　divide　the　interconnected　channels　into　isolated　cages.　This　structure　possesses　a　high　pore　volume　with　a　reduced　pore　size　and　a　functionalized　pore　surface　to　realize　preferential　binding　of　C2H6　over　C2H4.　Dynamic　breakthrough　measurements　demonstrated　that　BIF-108-Zn　can　directly　produce　polymer-grade　C2H4　with　a　productivity　of　0.69　mmol/g　at　298　K　and　1　bar　from　a　binary　mixture　of　C2H6/C2H4.　Furthermore,　the　relatively　low　isosteric　enthalpy　value　endows　it　with　good　regenerability　and　high　stability,　as　verified　by　multiple　adsorption　separation　tests.　©　2021　American　Chemical　Society.