The　endothelium　covers　the　internal　lumen　of　the　entire　circulatory　system　and　plays　an　important　modulatory　role　in　vascular　homeostasis.　Endothelium　dysfunction,　characterized　by　a　vasoconstrictive,　pro-inflammatory,　and　pro-coagulant　state,　usually　manifests　as　a　significant　pathological　process　of　vascular　diseases,　including　hypertension,　atherosclerosis　(AS),　stroke,　diabetes　mellitus,　coronary　artery　disease,　and　cancer.　Therefore,　there　is　an　urgent　necessity　to　seek　promising　therapeutic　drugs　or　remedies　to　ameliorate　endothelial　dysfunction-induced　vascular　ailments　and　complications.　Recently,　much　attention　has　been　attached　to　ginsenosides,　the　most　significant　active　components　of　ginseng,　which　have　always　been　referred　to　as　＂all-healing＂　and　widely　used　for　its　extensively　medicinal　value.　Surprisingly,　ginsenosides　have　diverse　biological　activity　which　might　be　related　to　inflammation,　apoptosis,　oxidative　stress,　and　angiogenesis.　In　this　review,　a　brief　introduction　about　endothelial　dysfunction　and　ginsenosides　was　demonstrated,　and　the　emphasis　was　put　on　summarizing　multi-faceted　pharmacological　effects　and　underlying　molecular　mechanisms　of　ginsenosides　on　the　endothelium,　including　vasorelaxation,　anti-oxidation,　anti-inflammation,　and　angio-modulation.　Beyond　that,　nanotechnology　to　improve　efficacy　and　the　existing　clinical　trials　of　ginsenosides　were　concluded.　Hopefully,　our　work　will　give　suggestions　for　promoting　clinical　application　of　traditional　Chinese　medicine,　e.g.,　hypertension,　AS,　diabetes,　ischemic　stroke,　and　cancer.　This　review　provides　a　comprehensive　base　of　knowledge　for　ginsenosides　to　prevention　and　treatment　of　vascular　injury-　related　diseases　with　clinical　significance.