The　search　for　polyoxometalate-based　catalysts　has　long　attracted　interest.　Being　designable　in　structure,　stable　and　effective,　polyoxoniobate-based　catalysts　have　an　exciting　prospect　for　industrial　applications.　This　paper　not　only　summarizes　recent　advances　in　classic　polyoxoniobate-catalyzed　reactions,　including　chemical　warfare　agents　and　organic　dyes　degradation,　epoxidation　reactions,　photocatalytic　hydrogen　evolution　and　base-catalyzed　reactions　but　also　discusses　some　representative　cases　and　the　speculative　mechanism　related　to　structures.　In　addition,　the　current　challenges　and　perspectives　in　the　fabrication　of　more　efficient　and　promising　polyoxoniobate-based　catalysts　are　also　presented.　©　2021,　The　Nonferrous　Metals　Society　of　China.