Persistent　organic　pollutants　(POPs)　have　received　significant　and　ongoing　attention.　To　establish　favorable　regulatory　policies,　it　is　vital　to　investigate　the　occurrence,　source,　and　budgets　of　POPs　worldwide.　POPs　including　phthalic　acid　esters　(PAEs),　organophosphate　esters　(OPEs),　brominated　flame　retardants　(BFRs),　and　highly　chlorinated　flame　retardants　(HFRs)　have　not　yet　been　examined　in　the　Eastern　Indian　Ocean　(EIO).　In　this　study,　the　distribution　of　POPs　has　been　investigated　from　surface　sediments　with　the　depth　of　4369-5742　m　in　the　Central　Indian　Ocean　Basin　(CIOB)　and　Wharton　Basin　(WB)　of　EIO.　The　average　(±SD)　concentrations　of　Σ11PAEs,　Σ11OPEs,　Σ4BFRs,　and　Σ5HFRs　were　1202.0　±　274.36　ng　g-1dw,　15.3　±　7.23　ng　g-1dw,　327.6　±　211.74　pg　g-1dw,　and　7.9　±　7.45　pg　g-1dw,　respectively.　The　high　abundance　of　low-molecular-weight　(LMW)　PAEs,　chlorinated　OPEs,　LMW　BDEs,　and　anti-Dechlorane　Plus　indicated　the　pollution　characteristics　in　the　EIO.　Correlation　analysis　demonstrated　that　LMW　compounds　may　be　derived　from　the　high-molecular-weight　compounds.　The　monsoon　circulation,　currents,　and　Antarctic　Bottom　Water　may　be　the　main　drivers.　POP　accumulation　rate,　depositional　flux,　and　mass　inventory　in　the　Indian　Ocean　were　also　estimated.　©　2022　American　Chemical　Society.　All　rights　reserved.