River　carrying　antibiotics　from　upstream　posed　serious　threats　to　receiving　lake,　and　plants　might　had　effects　on　antibiotics.　Therefore,　samples　of　waters,　sediments　and　tissues　of　cultivated　and　wild　Phragmites　australis　were　collected　to　analyse　antibiotics　fate　and　ecological　risks　(RQs)　in　Zaozhadian　Lake.　Our　results　revealed　that　the　total　antibiotics　showed　an　increasing　tendency　in　surface/pore　water　and　P.　australis　tissues　and　a　decreasing　tendency　in　overlying　water　and　sediments　from　the　lake　entrance　to　the　centre.　The　bioaccumulation　factors　(BAFs)　of　two　sulfonamides　(SAs)　and　three　quinolones　(QNs)　increased　in　sediments　and　decreased　in　those　of　erythromycin　in　pore　water　from　Site　1　to　Site　11.　Three　QNs　and　two　tetracyclines　(TCs)　were　dominant　antibiotics　in　pore　water/sediment　and　surface/overlying　water　respectively.　Higher　levels　of　two　SAs　in　surface/pore　water　and　two　macrolides　(MAs)　in　overlying/pore　water　and　sediments　were　observed　in　the　wild　P.　australis　region,　while　higher　values　of　two　TCs　in　overlying/pore　water　and　three　QNs　in　sediment　were　observed　in　the　cultivated　P.　australis　region.　Higher　BAFs　of　SAs　and　QNs　in　sediments　were　observed　in　the　cultivated　and　wild　P.　australis　region　respectively.　The　RQs　of　oxytetracycline　and　two　MAs　posed　moderate　risks　in　surface/overlying　water　from　more　than　50%　of　sampling　sites.　Norfloxacin　exhibited　moderate　RQ　and　low　∑RQ　levels　in　sediments,　and　showed　high　risk　in　pore　water.　Our　findings　imply　that　much　more　attention　should　be　given　to　the　antibiotics　from　river　inputs　and　management　normatives　to　control　antibiotic　pollution.　©　2022　Elsevier　Ltd