Membrane　wetting　and　fouling　substantially　limits　application　and　deployment　of　membrane　distillation　process.　Designing　high-performance　superhydrophobic　membranes　offers　an　effective　solution　to　solve　the　challenge.　In　this　work,　a　highly　durable　superhydrophobic　surface　(water　contact　angle　of　170.8　±　1.3°)　was　constructed　via　a　facile　and　rapid　spray-coating　of　extremely　hydrophobic　SiO2　nanoparticles　onto　a　porous　polyvinylidene　fluoride　(PVDF)　substrate　for　membrane　distillation.　The　superhydrophobic　membrane　coated　by　fluorinated　SiO2　nanoparticles　exhibited　a　superior　physicochemical　stability　in　a　wide　range　of　extreme　environments　(i.e.,　NaOH,　HCl,　hot　water,　rust　water,　humic　acid　solution,　ultrasonication,　and　high-speed　water　scouring).　During　8-h　continuous　membrane　distillation　desalination　experiment,　the　coated　superhydrophobic　membrane　experienced　a　consistently　stable　water　vapor　flux　(ca.　19.1　kg·m−2·h−1)　and　desalination　efficiency　(99.99　%).　Additionally,　such　a　stable　superhydrophobicity　endowed　the　spray-coated　PVDF　membrane　to　overcome　membrane　wetting　and　fouling　during　membrane　distillation　of　highly　saline　solutions　containing　foulants　(i.e.,　humic　acid　and　rust).　Results　reported　in　this　study　provides　a　useful　concept　and　strategy　in　facile　construction　of　robust　superhydrophobic　membranes　via　spray-coating　for　effective　membrane　distillation.　©　2022　Elsevier　B.V.