Synthetic　micro/nanomotors　have　great　potential　in　deep　tissue　imaging　and　in　vivo　drug　delivery　because　of　their　active　motion　ability.　However,　applying　nanomotors　with　a　size　less　than　100　nm　to　in　vivo　imaging　and　therapy　is　one　of　the　core　changes　in　this　field.　Herein,　a　nanosized　hydrogen　peroxide　(H2O2)-driven　Janus　gold　nanorod-platinum　(JAuNR-Pt)　nanomotor　is　developed　for　enhancing　the　second　near-infrared　region　(NIR-II)　photoacoustic　(PA)　imaging　of　deep　tissues　of　tumors　and　for　effective　tumor　treatment.　The　JAuNR-Pt　nanomotor　is　prepared　by　depositing　platinum　(Pt)　on　one　end　of　a　gold　nanorod　with　varying　proportions　of　Pt　shell　coverage,　including　10%,　25%,　50%,　75%,　and　100%.　The　JAuNR-Pt　nanomotor　with　Pt　shell　coverage　proportions　of　50%　exhibits　the　highest　diffusion　coefficient　(De),　and　it　can　rapidly　move　in　the　presence　of　H2O2.　The　self-propulsion　of　JAuNR-Pt　nanomotor　enhances　cellular　uptake,　accelerates　lysosomal　escape,　and　facilitates　continuous　release　of　cytotoxic　Pt2+　ions　to　the　nucleus,　causing　DNA　damage　and　cell　apoptosis.　The　JAuNR-Pt　nanomotor　presents　deep　penetration　and　enhanced　accumulation　in　tumors　as　well　as　high　tumor　treatment　effect.　Therefore,　this　work　displays　deep　tumor　imaging　and　an　excellent　antitumor　effect,　providing　an　effective　tool　for　accurate　diagnosis　and　treatment　of　diseases.