Prefabricated　beam–column　connections　are　the　most　vulnerable　components　of　prefabricated　buildings　during　earthquake　events.　The　seismic　performance　of　the　beam–column　connection　is　functional　as　the　critical　component　plays　a　key　role　in　structural　safety.　This　study　aimed　to　develop　a　novel　hybrid　prefabricated　concrete　(HPC)　connection,　combining　with　wet　and　dry　connection　techniques,　to　enhance　the　seismic　performance　of　prefabricated　concrete　frames.　A　quasi-static　experimental　investigation　was　carried　out　to　examine　the　seismic　performance　of　the　proposed　connection.　Two　full‐scale　prefabricated　connection　specimens　utilizing　the　proposed　HPC　connection　and　another　code‐defined　monolithic　prefabricated　concrete　(PC)　connection　were　tested　under　cyclic　loading,　keeping　the　axial　load　on　the　column　constant.　The　ductility,　stiffness　degra-dation,　energy　dissipation　capacity,　post‐tensioned　force,　and　residual　displacement　were　obtained　based　on　the　experimental　output.　The　results　indicated　that　the　HPC　connection　developed　had　high　construction　efficiency　and　better　seismic　performance　than　the　conventional　PC　connection.　The　strength　and　energy　dissipation　capacity　were　significantly　improved　by　up　to　52%　and　10%,　respectively.　The　cracking　and　stiffness　degradation　were　well‐controlled.　©　2022　by　the　authors.　Licensee　MDPI,　Basel,　Switzerland.