Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing - Details

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Abstract：

Electrical　stimulation　can　facilitate　wound　healing　with　high　efficiency　and　limited　side　effects.　However,　current　electrical　stimulation　devices　have　poor　conformability　with　wounds　due　to　their　bulky　nature　and　the　rigidity　of　electrodes　utilized.　Here,　a　flexible　electrical　patch　(ePatch)　made　with　conductive　hydrogel　as　electrodes　to　improve　wound　management　was　reported.　The　conductive　hydrogel　was　synthesized　using　silver　nanowire　(AgNW)　and　methacrylated　alginate　(MAA),　with　the　former　chosen　as　the　electrode　material　considering　its　antibacterial　properties,　and　the　latter　used　due　to　its　clinical　suitability　in　wound　healing.　The　composition　of　the　hydrogel　was　optimized　to　enable　printing　on　medical-grade　patches　for　personalized　wound　treatment.　The　ePatch　was　shown　to　promote　re-epithelization,　enhance　angiogenesis,　mediate　immune　response,　and　prevent　infection　development　in　the　wound　microenvironment.　In　vitro　studies　indicated　an　elevated　secretion　of　growth　factors　with　enhanced　cell　proliferation　and　migration　ability　in　response　to　electrical　stimulation.　An　in　vivo　study　in　the　Sprague-Dawley　rat　model　revealed　a　rapid　wound　closure　within　7　days　compared　to　20　days　of　usual　healing　process　in　rodents.　©　2022　Elsevier　Ltd

Keyword：

Antibacteria; Conductive hydrogel; Electrical stimulation; Wearable device; Wound healing

Community：

[ 1 ] [Wang, C.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 2 ] [Wang, C.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 3 ] [Wang, C.]Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 4 ] [Wang, C.]Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, United States
[ 5 ] [Jiang, X.]School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China
[ 6 ] [Kim, H.-J.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 7 ] [Kim, H.-J.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 8 ] [Kim, H.-J.]Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, United States
[ 9 ] [Zhang, S.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 10 ] [Zhang, S.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 11 ] [Zhang, S.]Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, SAR, China
[ 12 ] [Zhou, X.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 13 ] [Zhou, X.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 14 ] [Zhou, X.]Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States
[ 15 ] [Chen, Y.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 16 ] [Chen, Y.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 17 ] [Chen, Y.]Bloomage Biotechnology Co., Ltd., Shandong, Jinan, 250101, China
[ 18 ] [Chen, Y.]Bloomage Biotechnology Hainan Co.,Ltd., Hainan, Haikou, 571152, China
[ 19 ] [Ling, H.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 20 ] [Ling, H.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 21 ] [Ling, H.]Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 22 ] [Xue, Y.]State Key Laboratory of Solidification Processing, Center for Nano Energy Materials, School of Materials Science and Engineering, Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene, Xi'an, 710072, China
[ 23 ] [Chen, Z.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 24 ] [Chen, Z.]MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350108, China
[ 25 ] [Qu, M.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 26 ] [Qu, M.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 27 ] [Qu, M.]Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China
[ 28 ] [Ren, L.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 29 ] [Ren, L.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 30 ] [Ren, L.]Key Laboratory for Space Bioscience and Biotechnology, School of Life Science, Northwestern Polytechnical University, Shanxi, Xi'an, 710072, China
[ 31 ] [Ren, L.]Research Center of Microfluidic Chip for Health Care and Environmental Monitoring, Yangtze River Delta Research Institute of Northwestern Polytechnical University, Taicang, Jiangsu, Suzhou, 215400, China
[ 32 ] [Zhu, J.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 33 ] [Zhu, J.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 34 ] [Zhu, J.]Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, China
[ 35 ] [Zhu, J.]The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, China
[ 36 ] [Libanori, A.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 37 ] [Libanori, A.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 38 ] [Zhu, Y.]Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, United States
[ 39 ] [Kang, H.]Department of Materials Science and Engineering, Korea University, Seoul, 02841, South Korea
[ 40 ] [Ahadian, S.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 41 ] [Ahadian, S.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 42 ] [Ahadian, S.]Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, United States
[ 43 ] [Ahadian, S.]Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 44 ] [Dokmeci, M.R.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 45 ] [Dokmeci, M.R.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 46 ] [Dokmeci, M.R.]Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, United States
[ 47 ] [Dokmeci, M.R.]Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 48 ] [Servati, P.]Flexible Electronics and Energy Lab (FEEL), Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
[ 49 ] [He, X.]Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 50 ] [Gu, Z.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 51 ] [Gu, Z.]College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China
[ 52 ] [Gu, Z.]Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China
[ 53 ] [Gu, Z.]MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China
[ 54 ] [Gu, Z.]Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, 311121, China
[ 55 ] [Gu, Z.]Jinhua Institute of Zhejiang University, Jinhua, 321299, China
[ 56 ] [Gu, Z.]Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 57 ] [Sun, W.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 58 ] [Sun, W.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 59 ] [Sun, W.]Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, United States
[ 60 ] [Sun, W.]Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, United States
[ 61 ] [Khademhosseini, A.]Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 62 ] [Khademhosseini, A.]Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 63 ] [Khademhosseini, A.]Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, United States
[ 64 ] [Khademhosseini, A.]Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 65 ] [Khademhosseini, A.]Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, United States
[ 66 ] [Khademhosseini, A.]Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, United States

Reprint 's Address：

[Khademhosseini, A.]Terasaki Institute for Biomedical InnovationUnited States; ; Department of Biological Systems Engineering, Virginia Tech, United States; 电子邮件: sunw@vt.edu

Email：

khademh@terasaki.org Sun, W.

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Source ：

Biomaterials

ISSN： 0142-9612

Year： 2022

Volume： 285

1 4 . 0

JCR@2022

1 2 . 8 0 0

JCR@2023

ESI HC Threshold：91

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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