In　the　effort　to　accelerate　adsorption　and　catalytic　conversion　of　lithium　polysulfides　(Li-PSs)　and　suppress　the　shuttle　effect　of　lithium-sulfur　batteries　(LSBs),　the　Ti4O7　nanosheets/carbon　material-modified　separator　is　successfully　fabricated　to　reducing　soluble　Li-PSs’　crossover　from　cathode　to　anode.　The　catalyst　of　mesoporous　Ti4O7　nanosheets　with　O−Ti−O　units　synthesized　at　low　temperature　shows　both　excellent　conductivity　and　high　surface　area.　The　modified　separator　can　serve　as　a　diffusion　barrier　of　Li-PSs　and　catalyst　for　converting　soluble　low-chain　sulfides　into　insoluble　ones　and　then　remarkably　enhance　the　sulfur　utilization　and　electrochemical　performance　of　the　LSB.　This　work　provides　a　feasible　avenue　in　both　design　and　synthesis　of　mesoporous　catalyst　materials　for　suppressing　the　shuttle　effect　of　lithium-sulfur　batteries.　©　2022　Wiley-VCH　GmbH.