In　this　study,　we　reported　that　flash　sintering　(FS)　could　be　efficiently　triggered　at　room　temperature　(25　°C)　by　manipulating　the　oxygen　concentration　within　ZnO　powders　via　a　versatile　defect　engineering　strategy,　fully　demonstrating　a　promising　method　for　the　repaid　prototyping　of　ceramics.　With　a　low　concentration　of　oxygen　defects,　FS　was　only　activated　at　a　high　onset　electric　field　of　∼2.7　kV/cm,　while　arcs　appearing　on　the　surfaces　of　samples.　Strikingly,　the　onset　electric　field　was　decreased　to　＜　0.51　kV/cm　for　the　activation　of　FS　initiated,　which　was　associated　with　increased　oxygen　concentrations　coupled　with　increased　electrical　conductivity.　Thereby,　a　general　room-temperature　FS　strategy　by　introducing　intrinsic　structural　defect　is　suggested　for　a　broad　range　of　ceramics　that　are　prone　to　form　high　concentration　of　point　defects.　[Figure　not　available:　see　fulltext.].　©　2022,　The　Author(s).