Two-dimensional　nanoporous　membranes　are　promising　materials　for　seawater　desalination.　However,　the　effect　of　nanopore　charge　properties　on　desalination　performance,　especially　on　water　permeability,　has　not　yet　been　systematically　investigated.　In　this　work,　molecular　dynamics　simulations　were　carried　out　to　elucidate　the　impact　of　nanopore　charge　modification　(variated　from　0　to　1.0e)　on　water　permeability　and　ions　conduction.　The　highest　water　permeability　was　observed　when　the　modification　was　approximately　0.25e.　The　nanopore　charge　conditions　significantly　impacted　water　dynamic　behaviors,　leading　to　the　transition　of　water　transport　processes　from　continuum　state　to　non-continuum　state　with　the　increase　of　nanopore　charge.　In　addition,　we　found　that　the　positively　charged　nanopores　not　only　effectively　impede　cation　permeation,　but　also　strongly　impact　the　diffusion　behavior　of　anions.　This　work　unveils　in-depth　insights　into　the　mechanism　of　saline　water　transport　through　the　charge-modified　nanopores　and　highlights　the　importance　of　the　nanopore　charge　states　for　desalination.　Meanwhile,　it　provides　useful　guidelines　for　the　rational　design　of　optimal　nanoporous　membranes　in　the　future.　©　2022　Elsevier　B.V.