Constructing　heterojunction　has　been　considered　as　an　efficient　strategy　to　promote　the　separation　and　transfer　of　photogenerated　carriers　and　improve　redox　ability　of　single　photocatalyst.　Herein,　S-scheme　BiOBr/Bi2S3　heterojunction　with　surface　oxygen　vacancies　(OVs)　was　synthesized　in　situ　by　a　facile　hydrothermal　method.　The　as-prepared　photocatalyst　show　high　activity　for　CO2　photoreduction　with　pure　water.　The　yields　of　product　CO　and　CH4　are　as　high　as　100.8　and　8.5　µmol　g−1h−1,　which　are　17.5　and　13.5　times　higher　than　that　of　the　pristine　Bi2S3,　and　2.3　and　4.7　times　higher　than　that　of　the　pristine　BiOBr　respectively.　The　excellent　activity　of　the　BiOBr/Bi2S3　heterojunction　is　attributed　to　both　the　S-scheme　electron　structure　and　the　surface　OVs　of　the　component　BiOBr.　The　S-scheme　structure　can　enhance　utilization　of　sunlight　and　improve　the　separation　and　transfer　of　photogenerated　electron/hole　pairs.　The　surface　OVs　of　BiOBr　can　serve　as　active　sites　of　CO2　and　H2O　in　the　photocatalytic　process.　This　work　provides　some　novel　insights　of　S-scheme　heterojunction　with　defects　for　photocatalytic　CO2　reduction.　©　2022　Elsevier　Inc.