This　study　applied　a　panel　data　of　37　African　countries　in　examining　the　impact　of　trade　openness　and　foreign　direct　investment　on　sustainable　agriculture　towards　the　attainment　of　the　United　Nation　(UN)　Sustainable　Development　Goals　(SDGs),　especially,　SDG-2,　with　the　aim　of　ending　extreme　hunger,　achieve　food　security　and　improve　nutrition　and　promote　sustainable　agriculture.　Data　for　the　study　was　sourced　from　the　Country　Policy　and　Institutional　Assessment　(CPIA)　and　World　Development　Indicators　(WDI)　of　the　World　Bank,　for　the　period　2005　-2019.　To　control　for　endogeneity,　the　study　engaged　the　system　Generalised　Method　of　Moments　(GMM).　The　result　shows　that　FDI　and　trade　openness　have　significant　negative　impact　on　agricultural　sustainability　in　Africa.　This　result　implies　that,　increase　in　FDI　may　decrease　agricultural　sustainability　by　0.00294%,　while　increase　in　trade　openness　may　lower　agricultural　sustainability　by　0.430066　%.　Therefore,　the　study　concludes　that　while　trade　openness　is　negative,　policy　to　raise　local　production　towards　export　promotion　should　be　encouraged.　In　addition,　FDI　should　be　encouraged　to　augment　local　employment　and　investment　towards　increasing　output　and　productivity　in　the　Africa　region.