Self-ignition　may　occur　during　hydrogen　storage　and　transportation　if　high-pressure　hydrogen　is　suddenly　released　into　the　downstream　pipelines,　and　the　presence　of　obstacles　inside　the　pipeline　may　affect　the　ignition　mechanism　of　high-pressure　hydrogen.　In　this　work,　the　effects　of　multiple　obstacles　inside　the　tube　on　the　shock　wave　propagation　and　self-ignition　during　high-pressure　hydrogen　release　are　investigated　by　numerical　simulation.　The　RNG　k-ε　turbulence　model,　EDC　combustion　model,　and　19-step　detailed　hydrogen　combustion　mechanism　are　employed.　After　verifying　the　reliability　of　the　model　with　experimental　data,　the　self-ignition　process　of　high-pressure　hydrogen　release　into　tubes　with　obstacles　with　different　locations,　spacings,　shapes,　and　blockage　ratios　is　numerically　investigated.　The　results　show　that　obstacles　with　different　locations,　spacings,　shapes　and　blockage　ratios　will　generate　reflected　shock　waves　with　different　sizes　and　propagation　trends.　The　closer　the　location　of　obstacles　to　the　burst　disk,　the　smaller　the　spacing,　and　the　larger　the　blockage　ratio　will　cause　the　greater　the　pressure　of　the　reflected　shock　wave　it　produces.　Compared　with　the　tubes　with　rectangular-shaped,　semi-circular-shaped　and　triangular-shaped　obstacles,　self-ignition　is　preferred　to　occur　in　tube　with　triangular-shaped　obstacles.　©　2022　Hydrogen　Energy　Publications　LLC