CdS/Bi2WO6-S　nanocomposites,　in　which　small　cubic　CdS　nanoparticles　(ca.　4　nm)　assembled　on　thin　orthorhombic　Bi2WO6　nanosheets　(Bi2WO6-S),　were　fabricated　through　a　facile　precipitation　of　Cd2+　with　S2-　in　the　presence　of　orthorhombic　Bi2WO6　nanosheets　obtained　via　a　colloidal　two-phase　method.　As　a　result　of　the　presence　of　an　efficient　S-scheme　charge　transfer　pathway　between　CdS　and　Bi2WO6-S,　the　as-obtained　CdS/Bi2WO6-S　nanocomposites　exhibit　superior　activity　for　photocatalytic　CO2　reduction　to　generated　CO　and　CH4　under　visible　light,　with　an　optimum　performance　observed　over　the　0.5　CdS/Bi2WO6-S　nanocomposite.　The　obvious　superior　activity　over　the　0.5　CdS/Bi2WO6-S　nanocomposite　compared　to　that　over　the　0.5　CdS/Bi2WO6-B　nanocomposite,　in　which　cubic　CdS　nanoparticles　were　deposited　on　bulk　Bi2WO6,　highlights　the　importance　of　a　rational　interface　engineering　in　the　fabrication　of　the　S-scheme　heterojunction　photocatalytic　systems.　This　work　demonstrates　that　both　a　rational　selection　of　two　photocatalysts　with　staggered　band　alignment　and　a　delicate　tuning　of　their　interface　are　important　in　the　fabrication　of　the　S-scheme　heterojunction　to　realize　an　efficient　photocatalysis.　©　2022　American　Chemical　Society.