BACKGROUND:　Naringin,　the　active　ingredient　of　Rhizoma　Drynariae,　has　the　traditional　effect　of　strengthening　the　liver　and　kidney　and　strengthening　the　bones　and　muscles,　increasing　the　thickness　of　the　callus　and　improving　the　quality　of　fracture　healing.　OBJECTIVE:　To　explore　the　bone　conduction　and　bone　induction　properties　of　naringin-chitosan/hydroxyapatite　composite　scaffolds.　METHODS:　The　hydroxyapatite　precursor　solution　with　a　certain　calcium　to　phosphorus　ratio　and　the　chitosan　solution　containing　naringin　were　crystallized　in　situ　under　alkaline　conditions　and　freeze-dried　to　obtain　a　naringin-chitosan/hydroxyapatite　porous　scaffold.　A　total　of　15　SD　rats　were　randomly　divided　into　blank　group　(n=5),　control　group　(n=5)　and　experimental　group　(n=5).　The　5　mm-diameter　skull　bone　defect　models　were　established　by　drilling　holes.　Biomaterials　were　not　filled　in　the　blank　group.　Chitosan/hydroxyapatite　scaffolds　were　filled　in　the　control　group,　and　naringin-chitosan/hydroxyapatite　scaffolds　were　filled　in　the　experimental　group.　At　4　weeks　after　surgery,　CT　scans　were　performed　to　observe　the　skull　repair.　Hematoxylin-eosin　staining　was　used　to　observe　morphological　differences.　Immunohistochemical　staining　of　bone　morphogenetic　protein　2　and　vascular　endothelial　growth　factor　was　performed　to　observe　the　expression　of　local　osteogenic　active　factors　in　the　defect　areas.　RESULTS　AND　CONCLUSION:　(1)　CT　scan　showed　that　no　obvious　osteogenesis　was　seen　in　the　skull　of　rats　in　the　blank　group,　only　a　small　amount　of　new　bone　was　seen　at　the　edge　of　the　defect.　In　the　control　group,　new　bone　formation　could　be　seen　in　the　defect　pores,　and　there　was　less　new　bone.　In　the　experimental　group,　the　bone　defect　was　well　repaired,　the　density　of　new　bone　tissue　and　the　skull　around　the　defect　pores　were　similar,　and　a　large　area　of　new　bone　widely　filled　the　defect　pores.　(2)　Hematoxylin-eosin　staining　showed　that　the　defect　area　in　the　blank　group　was　filled　with　thin　loose　reticular　fibrous　tissue,　and　a　large　number　of　inflammatory　response　lesions　were　seen,　and　only　a　small　amount　of　new　bone　was　formed　at　the　edge　of　the　defect.　In　the　control　group　and　the　experimental　group,　residual　scaffold　material,　new　bone　trabecula　and　osteoblasts　were　seen　in　the　defect　area,　osteoblasts　were　distributed　in　clusters　in　the　pores　of　the　scaffold　and　the　edges　of　the　defect　area,　surrounded　by　a　large　number　of　capillaries.　Among　them,　the　experimental　group　showed　a　stronger　ability　of　new　bone　growth.　(3)　Immunohistochemical　staining　showed　that　the　expression　levels　of　local　osteogenic　activity　factors　bone　morphogenetic　protein　2　and　vascular　endothelial　growth　factor　in　the　experimental　group　were　higher　than　those　in　the　control　and　blank　groups　(P　＜　0.05).　(4)　The　results　conclude　that　naringin-chitosan/hydroxyapatite　composite　scaffolds　can　provide　necessary　carrier　for　bone　defect　repair.　Naringin　can　create　local　osteogenic　microenvironment,　accelerate　the　growth　and　mineralization　of　new　bone　tissue,　and　have　good　bone　repair　performance.　©　2022,　Publishing　House　of　Chinese　Journal　of　Tissue　Engineering　Research.　All　rights　reserved.