Fabrics　have　been　used　broadly　in　daily　life　for　an　enormous　variety　of　applications　due　to　their　intrinsic　advantages,　such　as　flexibility,　renewability,　and　good　processability.　Integrating　natural　fabrics　with　metal-organic　frameworks　(MOFs)　is　an　effective　strategy　to　improve　the　added　value　of　textiles　with　special　functionalities.　Here,　a　facile,　low-cost,　and　scalable　technology　is　reported　for　the　in　situ　growth　of　MOFs　on　cotton　fabrics.　A　uniform　and　dense　coating　of　regular　octahedral　Cu-1,3,5-benzenetricarboxylic　acid　(CuBTC)　crystals　was　formed　on　the　fiber　surface,　followed　by　treatment　with　1H,1H,2H,2H-perfluorooctyltriethoxysilane　and　triethoxyoctylsilane　to　create　a　superhydrophobic　CuBTC@cotton　fabric　(SMCF),　which　greatly　improved　its　water　stability　and　extended　superhydrophobic　CuBTC＇s　potential　applications.　The　as-prepared　MCF　has　a　specific　surface　area　of　229　m2/g,　which　is　11　times　that　of　pristine　fabrics　(21　m2/g).　This　high　porosity　further　endows　the　fabric　with　enhanced　loading　capacity　of　essential　oils　to　enable　excellent　antibacterial　ability.　Moreover,　the　SMCF　also　exhibits　excellent　self-cleaning,　UV　shielding,　and　anti-icing　performances.　In　addition,　we　performed　COMSOL　simulations　to　investigate　the　dynamic　freezing　process　of　water　on　the　surface　of　samples,　which　agrees　well　with　our　experimental　observations.　By　combining　the　merits　of　both　fabrics　and　MOFs,　the　MCF　is　expected　to　extend　the　applications　of　traditional　textiles　in　antifouling,　safety,　the　fragrance　industry,　and　healthcare　for　the　next-generation　multifunctional　fabrics.　©　2022　American　Chemical　Society.