Inducing　redox　imbalance　in　cancer　cells　aided　by　external　stimuli　is　a　promising　strategy　to　treat　cancer.　However,　maximizing　efficacious　reactive　species　content　with　durable　effects　in　deep　tumors　remains　to　be　challenging.　Here,　we　report　an　herbal　medicine-based　nanoreactor　(OH7)　self-assembled　by　oleanolic　acid　(OA)　and　two　sonosensitizers.　OH7　couples　two　cascade　reactions　under　sonication,　including　dual-sonosensitizer-participated　consecutive　reactions　for　generating　long-living　peroxyl　radical　(ROO　center　dot)　and　OA-participated　se-rial　reactions　for　forming　highly　cytotoxic　peroxynitrite　(ONOO-).　The　site-directed　reactive　species　burst　exerts　excellent　cytotoxicity　on　two-dimensional　cancer　cell　cultures　and　multicellular　tumor　spheroids.　The　high　elasticity　of　OH7　for　deep　tumor　transportation,　the　enhanced　intratumoral　convection　by　ultrasound,　and　the　formation　of　ONOO-　to　destroy　extracellular　matrix　jointly　facilitate　satisfactory　penetration　depth　of　sono-sensitizers.　Of　note,　the　deep　penetration　and　the　long-lived　hypertoxic　reactive　species　generating　ability　can　realize　effective　tumor　inhibition　by　systemic　administration.　This　study　opens　up　new　insights　into　the　reactive　species-related　bioactive　mechanisms　to　support　green　development　of　biocompatible　high-performance　sono-catalytic　nanoreactor　for　potential　clinical　applications.