The　poor　water　solubility,　bioavailability　and　stability　of　bioactive　compounds　have　become　the　bottleneck　restricting　their　wide　application,　thus　developing　a　functional　carrier　to　realize　the　efficient　encapsulation　and　activity　improvement　of　active　hydrophobic　substances　has　become　a　research　hotspot.　In　this　work,　a　functional　glycosylated　fish　gelatin　(called　FG-COS　conjugates)　carrier　based　on　fish　gelatin　(FG)　and　chitooligosaccharide　(COS)　via　Maillard　reaction　was　developed.　The　functional　carrier　exhibited　good　antioxidant　activity　and　high　encapsulation　of　curcumin　(Cur).　Enhanced　antioxidant　effect　of　Cur　loaded　in　FG-COS　conjugates　(called　FG-COS-Cur　nanoparticles)　was　achieved,　showing　remarkable　UV　protection　on　Cur　and　enhanced　intracellular　antioxidant　activity　of　FG-COS-Cur　nanoparticles.　Remarkably,　FG-COS-Cur　nanoparticles　increased　the　cell　viability　of　H2O2-induced　oxidative　damage　Caco-2　cells,　drastically　reduced　the　levels　of　reactive　oxygen　species　(ROS)　and　lactate　dehydrogenase　(LDH),　and　significantly　increased　intracellular　antioxidant　enzyme　activities,　which　all　exhibited　a　dose-response　relationship.　These　findings　suggested　that　the　FG-COS　conjugates　with　intrinsic　antioxidant　activity　could　effectively　encapsulate　Cur　and　improved　bioavailability　for　hydrophobic　active　molecules　in　functional　food　field.