Monascus　pigments　(MPs)　are　natural　edible　pigments　with　high　safety　and　strong　function,　which　have　been　widely　used　in　food　and　health　products.　In　this　study,　different　types　of　tea　extracts　(rich　in　polyphenols)　were　used　to　regulate　the　biosynthesis　of　MPs.　The　results　showed　that　15%　ethanol　extract　of　pu-erh　tea　(T11)　could　significantly　increase　MPs　production　in　liquid　fermentation　of　Monaco＇s　purpureus　M3.　Comparative　transcriptomic　and　metabolomic　analyses　combined　with　reverse　transcription-quantitative　polymerase　chain　reaction　(RT-qPCR)　were　used　to　further　explore　the　regulatory　mechanism　of　T11　on　the　biosynthesis　of　MPs.　Comparative　transcriptomic　analysis　showed　that　there　were　1503　differentially　expressed　genes　(DEGs)　between　the　Con　group　and　the　T11　group,　which　were　mainly　distributed　in　carbohydrate　metabolism,　amino　acid　metabolism,　energy　metabolism,　lipid　metabolism,　metabolism　of　terpenoids　and　polyketides,　etc.　A　total　of　115　differential　metabolites　(DMs)　identified　by　metabolomics　between　the　Con　and　T11　groups　were　mainly　enriched　in　glutathione　metabolism,　starch　and　sucrose　metabolism,　alanine,　aspartic　acid　and　glutamate　metabolism　and　glycine,　serine　and　threonine　metabolism,　etc.　The　results　of　metabolomics　were　basically　consistent　with　those　of　gene　transcriptomics,　indicating　that　the　regulatory　effect　of　T11　on　the　biosynthesis　of　MPs　is　mainly　achieved　through　affecting　the　primary　metabolic　pathway,　providing　sufficient　energy　and　more　biosynthetic　precursors　for　secondary　metabolism.　In　this　study,　tea　extracts　with　low　economic　value　and　easy　access　were　used　as　promoters　of　MPs　biosynthesis,　which　may　be　conducive　to　the　application　of　MPs　in　large-scale　industrial　production.　At　the　same　time,　a　more　systematic　understanding　of　the　molecular　regulatory　mechanism　of　Monascus　metabolism　was　obtained　through　multi-omics　analysis.