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author:

Hu, Ziwei (Hu, Ziwei.) [1] | Deng, Yanglin (Deng, Yanglin.) [2] | Lan, Junlin (Lan, Junlin.) [3] | Wang, Tao (Wang, Tao.) [4] | Han, Zixin (Han, Zixin.) [5] | Huang, Yuxiu (Huang, Yuxiu.) [6] | Zhang, Hejun (Zhang, Hejun.) [7] | Wang, Jianchao (Wang, Jianchao.) [8] | Cheng, Musheng (Cheng, Musheng.) [9] | Jiang, Haiyan (Jiang, Haiyan.) [10] (Scholars:姜海燕) | Lee, Ren-Guey (Lee, Ren-Guey.) [11] | Du, Ming (Du, Ming.) [12] | Tong, Tong (Tong, Tong.) [13] (Scholars:童同) | Gao, Qinquan (Gao, Qinquan.) [14] (Scholars:高钦泉) | Chen, Gang (Chen, Gang.) [15]

Indexed by:

EI Scopus SCIE

Abstract:

Perineural invasion (PNI) is the process of neoplastic invasion of the nerves and is a prognostic factor in gastric cancer. However, such examination is a labor-intensive task in high-resolution digital pathological images. To alleviate this problem, we propose a multi-task deep learning-based framework to highlight diagnostically significant PNI regions in whole slide images (WSIs) of human gastric cancer tissue sections. The proposed framework includes a gastric cancer segmentation model, neural detection model, and PNI decision-making module, which realizes the segmentation of the gastric cancer region while completing the task of identifying PNI. Adequate comparative experiments were performed on our own gastric cancer PNI dataset called GC-PNI. Experiments have shown that our proposed model can effectively diagnose PNI with a high sensitivity of 0.972 and a specificity of 0.933, illustrating the potential of this practical application.

Keyword:

Deep learning Gastric cancer segmentation Perineural infiltration detection Transformer Whole slide images

Community:

  • [ 1 ] [Hu, Ziwei]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 2 ] [Deng, Yanglin]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 3 ] [Lan, Junlin]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 4 ] [Wang, Tao]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 5 ] [Han, Zixin]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 6 ] [Huang, Yuxiu]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 7 ] [Du, Ming]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 8 ] [Tong, Tong]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 9 ] [Gao, Qinquan]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China
  • [ 10 ] [Hu, Ziwei]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 11 ] [Deng, Yanglin]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 12 ] [Lan, Junlin]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 13 ] [Wang, Tao]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 14 ] [Han, Zixin]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 15 ] [Huang, Yuxiu]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 16 ] [Jiang, Haiyan]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 17 ] [Du, Ming]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 18 ] [Tong, Tong]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 19 ] [Gao, Qinquan]Fuzhou Univ, Fujian Key Lab Med Instrumentat & Pharmaceut Techn, Fuzhou 350108, Fujian, Peoples R China
  • [ 20 ] [Tong, Tong]Imperial Vis Technol, Fuzhou 350002, Peoples R China
  • [ 21 ] [Gao, Qinquan]Imperial Vis Technol, Fuzhou 350002, Peoples R China
  • [ 22 ] [Chen, Gang]Fujian Prov Key Lab Translat Canc Med, Fuzhou 350014, Peoples R China
  • [ 23 ] [Jiang, Haiyan]Fuzhou Univ, Coll Elect Engn & Automat, Fuzhou 350108, Fujian, Peoples R China
  • [ 24 ] [Lee, Ren-Guey]Natl Taipei Univ Technol, Dept Elect Engn, Taipei 10608, Taiwan
  • [ 25 ] [Du, Ming]Wuyi Univ, Fujian Prov Key Lab Ecoind Green Technol, Wuyishan 354300, Peoples R China
  • [ 26 ] [Zhang, Hejun]Fujian Med Univ, Fujian Canc Hosp, Canc Hosp, Dept Pathol, Fuzhou 350014, Peoples R China
  • [ 27 ] [Wang, Jianchao]Fujian Med Univ, Fujian Canc Hosp, Canc Hosp, Dept Pathol, Fuzhou 350014, Peoples R China
  • [ 28 ] [Cheng, Musheng]Fujian Med Univ, Fujian Canc Hosp, Canc Hosp, Dept Pathol, Fuzhou 350014, Peoples R China
  • [ 29 ] [Chen, Gang]Fujian Med Univ, Fujian Canc Hosp, Canc Hosp, Dept Pathol, Fuzhou 350014, Peoples R China

Reprint 's Address:

  • [Gao, Qinquan]Fuzhou Univ, Coll Phys & Informat Engn, Fuzhou 350108, Fujian, Peoples R China;;[Chen, Gang]Fujian Med Univ, Fujian Canc Hosp, Canc Hosp, Dept Pathol, Fuzhou 350014, Peoples R China;;

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Source :

BIOMEDICAL SIGNAL PROCESSING AND CONTROL

ISSN: 1746-8094

Year: 2023

Volume: 79

4 . 9

JCR@2023

4 . 9 0 0

JCR@2023

ESI Discipline: ENGINEERING;

ESI HC Threshold:35

JCR Journal Grade:1

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 12

SCOPUS Cited Count: 15

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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