The　nanocarrier-based　drug　delivery　systems　have　become　an　alternative　strategy　for　cancer　treatment.　Whereas,　increasing　studies　find　that　the　utilization　of　drug　carriers　may　result　in　poor　biocompatibility,　lower　drug　loading　capacity　and　unpredictable　side　reactions.　Therefore,　we　herein　reported　self-assembled　micelles　based　on　herbal　product　ginsenosides,　which　are　the　main　active　ingredients　of　Panax　ginseng　C.A.　The　ginsenosides-based　micelle　system　exerts　excellent　biosafety,　better　stability,　high　drug　capacity,　and　lower　cytotoxicity　compared　to　free　ginsenosides.　Meanwhile,　ginsenosides　micelles　exhibits　superior　inhibitory　effects　on　cancer　cell　adhesion　activity,　especially　the　expression　of　intercellular　adhesion　molecule-1,　which　is　the　critical　factor　of　cancer　metastasis.　Importantly,　ginsenosides　micelles　results　in　remarkably　therapeutic　efficacy　on　lung　metastasis　of　liver　cancer.　All　these　results　highlight　the　potential　utilization　of　ginsenosides　micelles　in　the　clinic.　Meanwhile,　the　carrier-free　nano-drugs　self-delivery　system　of　ginsenosides　showed　great　promise　to　become　an　emerging　approach　for　cancer　metastasis　therapy.　©　2022　The　Korean　Society　of　Industrial　and　Engineering　Chemistry