In　this　study,we　reported　that　flash　sintering(FS)could　be　efficiently　triggered　at　room　temperature(25℃)by　manipulating　the　oxygen　concentration　within　ZnO　powders　via　a　versatile　defect　engineering　strategy,fully　demonstrating　a　promising　method　for　the　repaid　prototyping　of　ceramics.With　a　low　concentration　of　oxygen　defects,FS　was　only　activated　at　a　high　onset　electric　field　of～2.7　kV/cm,while　arcs　appearing　on　the　surfaces　of　samples.Strikingly,the　onset　electric　field　was　decreased　to＜0.51　kV/cm　for　the　activation　of　FS　initiated,which　was　associated　with　increased　oxygen　concentrations　coupled　with　increased　electrical　conductivity.Thereby,a　general　room-temperature　FS　strategy　by　introducing　intrinsic　structural　defect　is　suggested　for　a　broad　range　of　ceramics　that　are　prone　to　form　high　concentration　of　point　defects.