Although　photodynamic　therapy　(PDT)　has　attracted　great　interest,　the　photosensitizers　in　clinical　had　weak　inhibition　on　metastasis　and　invasion　of　cancers.　Additionally　the　immune　response　induced　by　PDT　was　insufficient　to　eradicate　cancer.　Herein,　indoximod,　an　inhibitor　of　indoleamine　2,3-dioxygenase　(IDO),　is　introduced　to　concatenate　with　zinc　phthalocyanines　(ZnPc)　for　effectively　overcoming　above　inadequacy.　Due　to　indoximod　moiety,　photosensitizer　1-MT-Pc　can　obtain　enhanced　intracellular　uptake　and　high　reactive　oxygen　species　(ROS)　generation.　More　impressively,　1-MT-Pc　can　achieve　remarkable　photocytotoxicity　towards　TNBC　cells　and　negligible　damage　to　normal　cells.　Meanwhile,　1-MT-Pc　effectively　inhibits　metastasis　and　invasion　of　TNBC　cells.　Importantly,　1-MT-Pc　exhibit　elevated　inhibitory　effect　on　4T1　tumor　by　enhanced　PDT　and　immunotherapy.　©　2022　Elsevier　Masson　SAS