A novel Pim-1 kinase-targeted photosensitizer to combat triple-negative breast cancer with enhanced photodynamic efficacy and reduced metastasis - Details

author：

Huang, K. (Huang, K..) ^[1] | Yang, S. (Yang, S..) ^[2] | Zhang, Y. (Zhang, Y..) ^[3] | Xue, J. (Xue, J..) ^[4] | Chen, J. (Chen, J..) ^[5]

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Abstract：

As　one　of　the　most　malignant　breast　cancer　types,　triple-negative　breast　cancer　(TNBC)　treatment　is　a　particularly　great　challenge　in　the　current　era　of　precision　medicine.　Due　to　the　limited　effectiveness　and　targeting　of　current　treatment　methods,　it　is　urgently　need　to　develop　an　effective　precision　strategy　to　combat　TNBC.　Herein,　a　novel　TNBC　targeted　molecular　drug　based　on　zinc(II)　phthalocyanine　(BF-Pc)　was　rationally　designed　by　conjugating　a　Pim-1　kinase　inhibitor　with　high　TNBC　selectivity.　In　our　in　vitro　investigation,　BF-Pc　not　only　exhibits　extremely　high　targeting　to　TNBC　cells　overexpressed　Pim-1　kinases,　but　also　shows　ultra-efficient　photocytotoxicity　toward　TNBC　cells　far　beyond　the　normal　cells.　Significantly,　BF-Pc-induced　PDT　can　obviously　suppress　TNBC　cell　migration　and　invasion.　The　proposed　manner　in　our　work　offers　a　promising　approach　to　combat　TNBC　effectively　and　precisely.　©　2022　Elsevier　Ltd

Keyword：

Invasion Migration Photodynamic therapy Pim-1 kinase Targeting Triple-negative breast cancer

Community：

[ 1 ] [Huang, K.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 2 ] [Yang, S.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 3 ] [Zhang, Y.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 4 ] [Xue, J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China
[ 5 ] [Chen, J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fujian, Fuzhou, 350116, China

Reprint 's Address：

[Chen, J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian, China

Email：

chenjuanjuan@fzu.edu.cn

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Source ：

Dyes and Pigments

ISSN： 0143-7208

Year： 2022

Volume： 207

4 . 5

JCR@2022

4 . 1 0 0

JCR@2023

ESI HC Threshold：74

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 2

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