Biomass-derived　fast　pyrolysis　liquids　(PLs)　are　not　directly　applicable　as　transportation　fuels　due　to　their　high　oxygen　content　and　limited　storage　stability.　Catalytic　hydrotreatment　is　an　efficient　technology　to　convert　such　PLs　to　finished　fuels　or　intermediates　that　can　be　used　as　a　co-feed　for　existing　oil　refinery　units.　In　this　paper,　we　report　catalyst　screening　studies　for　the　mild　hydrotreatment　of　PLs　using　commercially　available　Ni　and　Cu-based　PRICAT　catalysts　at　rather　mild　conditions　(200　°C,　initial　140　bar　H2pressure)　in　a　batch　setup　for　4　h.　Among　all　catalysts,　PRICAT　NI　62/15　showed　the　best　performance　for　mild　catalytic　hydrotreatment　in　terms　of　product　properties　(highest　H/C　ratio　and　lowest　TG　residue).　The　best　catalysts　were　also　tested　for　deep　hydrotreatment　at　more　severe　conditions　(350　°C,　initial　100　bar　H2pressure).　Here,　the　PRICAT　NI　catalysts　showed　better　performance　than　the　benchmark　Picula　Ni-Mo　catalyst　when　considering　oil　yield　and　H/C　ratio.　Advantageously,　the　hydrogen　consumption　during　deep　hydrotreatment　is　also　reduced,　rationalized　by　a　lower　methanation　activity.　©　2022　American　Chemical　Society.　All　rights　reserved.