Multi-story　reinforced　concrete　(RC)　frames　are　one　of　the　most　widely-used　structural　systems　in　engineering　practice.　To　prevent　the　progressive　collapse　of　RC　frames　under　disastrous　events,　it　is　desirable　to　systematically　investigate　the　progressive　collapse　fragility　of　the　structures　under　column　loss　scenarios.　This　study　proposed　a　simplified　procedure　for　quantifying　the　progressive　collapse　fragility　of　multi-story　RC　frames,　taking　into　consideration　the　influences　of　dynamic　effects　and　parameter　uncertainties.　Nine　typical　RC　frames　were　designed　according　to　the　Chinese　building　codes　and　investigated　by　the　proposed　method.　The　effects　of　seismic　design　intensity　and　the　number　of　stories　on　the　progressive　collapse　fragility　of　the　RC　frames　were　investigated.　The　results　indicate　that　the　progressive　collapse　resistance　of　multi-story　RC　frames　depends　on　the　combining　effects　of　the　structural　loads　and　the　bearing　capacity　of　the　beams.　The　structural　resistance　generally　improves　when　increasing　the　number　of　stories.　In　contrast,　it　improves　with　the　increase　of　seismic　design　intensity　only　when　the　seismic　load　is　involved　in　the　controlled　load　combination.　For　the　RC　frames　that　have　various　componential　dimensions　along　the　height,　the　stories　with　a　changed　componential　dimension　tend　to　collapse　more　likely　under　column　removal　scenarios.　The　outcomes　of　this　study　can　provide　references　for　quanti-fying　the　progressive　collapse　resistance　and　recommending　appropriate　load　increase　factors　for　the　engineering　design　of　multi-story　RC　frames　in　China.