Bisphenol　compounds　(BPs)　have　recently　been　the　subject　of　growing　interest　due　to　their　wide　use　in　industrial　and　consumer　products.　Besides　their　adverse　effects　on　human　endocrine　system,　effective　extraction　of　BPs　and　their　elimination　from　complex　sample　matrix　are　still　significant　challenges　in　food　analysis.　Herein,　a　novel　Zr(IV)-based　metal-organic　framework　(MOF),　named　BUT-16,　has　been　synthesized　and　utilized　for　the　extraction　and　enrichment　of　BPs　in　milk　samples.　Bisphenol　A　(BPA),　one　of　the　highest　production　volume　BPs,　is　used　as　a　model　molecule.　The　uptake　capacity　for　BPA　can　reach　up　to　48　mg/　g,　and　the　adsorption　rate　is　rapid　(similar　to　10　min),　because　of　the　larger　surface　area　and　cooperation　of　multiple　functionalities　of　BUT　16.　Employing　BUT-16　in　solid-phase　extraction,　coupled　with　ultra-performance　liquid　chromatography-tandem　mass　spectrometry　detection,　we　generated　a　rapid,　facile,　and　robust　method　for　the　enrichment　and　detection　of　trace　BPA　and　its　12　substitutes　in　milk　samples.　After　optimization,　the　limits　of　detection　and　quantification　for　BPs　can　be　achieved　as　low　as　0.05　and　0.2　ng/mL,　respectively.　Without　the　correction　of　the　isotopic　internal　standard,　the　average　recoveries　of　BPs　at　the　different　spiked　concentrations　varied　from　63.8　to　120.6%,　with　a　satisfactory　precision　(RSD　＜=　8.2%).　Furthermore,　the　proposed　method　was　successfully　applied　to　the　detection　of　BPs　in　real　milk　samples,　and　the　results　were　in　accordance　with　those　of　methods　reported　previously.