Immune　checkpoint　blockade　(ICB)　is　emerging　as　a　promising　therapeutic　approach　for　clinical　treatment　against　various　cancers.　However,　ICB　based　monotherapies　still　suffer　from　low　immune　response　rate　due　to　the　limited　and　exhausted　tumor-infiltrating　lymphocytes　as　well　as　tumor　immunosuppressive　microenvironment.　In　this　work,　the　cell　membrane　with　surface　displaying　PD-1　proteins　(PD1-CM)　was　prepared　for　immune　checkpoint　blockade,　which　was　further　combined　with　multifunctional　and　biodegradable　MnO2　for　systematic　and　robust　antitumor　therapy.　The　MnO2-based　gene-engineered　nanocomposites　can　catalyze　the　decomposition　of　abun-dant　H2O2　in　TME　to　generate　O2,　which　can　promote　the　intratumoral　infiltration　of　T　cells,　and　thus　improve　the　effect　of　immune　checkpoint　blockade　by　PD-1　proteins　on　PD1-CM.　Furthermore,　MnO2　in　the　nanocomposites　can　be　completely　degraded　into　Mn2　thorn　,　which　can　catalyze　the　generation　of　highly　toxic　hydroxyl　radicals　for　chemodynamic　therapy,　thereby　further　enhancing　the　therapeutic　effect.　In　addition,　the　prepared　nano　-composites　possess　the　advantages　of　low　cost,　easy　preparation　and　good　biocompatibility,　which　are　expected　to　become　promising　agents　for　combination　immunotherapy.