Tissue　engineering　scaffolds　with　tunable　viscoelasticity　and　adaptability　for　cell　behavior　and　fate　regulation　are　highly　desired.　Here　a　dynamic　interpenetrating　polymer　network　(IPN)　hydrogel　was　fabricated　via　photopolymerization　and　oxidation　of　methacryloyl　gelatin　(GelMA)　and　hyaluronic　acid　(HASH).　The　permanent　GelMA　network　formed　by　C[sbnd]C　bonds　provides　stable　support　for　cells　while　the　dynamic　HASH　network　formed　by　disulfide　bonds　provides　an　adaptable　microenvironment　for　cell　growth.　The　proposed　IPN　hydrogel　exhibits　extensive　and　tunable　porosity,　swelling,　degradation,　and　mechanical　properties.　Remarkably,　the　dynamic　IPN　hydrogel　mimics　the　viscoelasticity　and　adaptability　of　the　extracellular　matrix　(ECM),　which　can　regulate　cellular　behaviors　such　as　morphogenesis,　alignment,　proliferation,　migration　while　offering　resistance　to　cell　mediated　shrinkage　and　enzymatic　digestion,　maintaining　the　structural　integrity　of　the　scaffold.　Our　results　suggest　that　dynamic　IPN　3/7　(HASH/GelMA)　hydrogels　had　more　similar　physical　properties　to　human　skin　and　were　more　favorable　for　human　skin　fibroblasts　(HSF)　and　human　immortalized　keratinocytes　(HaCaT)　growth.　Moreover,　bilayer　tissue-engineered　skin　prepared　using　the　dynamic　IPN　hydrogel　exhibited　satisfactory　mechanical　stability,　dermal-epidermal　stratification,　matrix　secretion,　structural　differentiation,　and　barrier　functions.　In　addition,　the　bilayer　tissue-engineered　skin　can　significantly　promote　healing　of　full-thickness　skin　defects　through　accelerated　wound　re-epithelialization,　collagen　deposition,　and　angiogenesis,　without　causing　non-specific　or　specific　immune　rejection.　This　work　based　on　the　novel　dynamic　IPN　hydrogel　with　biomimetic　viscoelasticity　and　adaptability　demonstrates　the　promising　application　in　tissue　engineering.　©　2023　Elsevier　B.V.