Pt-based　catalysts　as　one　of　the　most　used　industrial　catalysts　in　heterogeneous　catalysis,　it　is　essential　for　the　on-purpose　catalytic　dehydrogenation　of　propane　to　propylene　(PDH).　Here,　the　highly　dispersed　PtCe　clusters　are　constructed　by　high-silica　Beta　zeolite　as　support　to　improve　the　catalytic　stability　and　propylene　selectivity　in　the　PDH　reaction.　The　defect　sites　derived　from　silanol　nests　are　responsible　for　dispersing　PtCe　clusters　inside　the　channels　of　the　high-silica　Beta-557　zeolite,　while　the　trace　Al　sites　play　an　important　role　in　further　stabilizing　the　active　site　structure　by　regulating　the　metal-support　interaction.　The　closely　associated　Pt　and　Ce　species　are　critical　to　embody　the　outstanding　catalytic　activity　(propane　conversion　of　∼42.2%,　propylene　selectivity　of　∼91.9%)　with　excellent　stability　(deactivation　constant:　0.013　h−1)　at　550　°C.　This　work　proposed　an　efficient　strategy　for　designing　stable　PtCe　bimetallic　clusters　by　utilizing　silanol　nests　and　Al　sites　to　regulate　the　metal-support　interaction　synergistically.　©　2023　Elsevier　Ltd