Therapeutic　modalities　and　drug　formulations　play　a　crucial　and　prominent　role　in　actualizing　effective　treatment　and　radical　cures　of　tumors.　However,　the　therapeutic　efficiency　was　severely　limited　by　tumor　recurrence　and　complex　multi-step　preparation　of　formulation.　Therefore,　the　exploration　of　novel　nanoparticles　via　a　simple　and　green　synthesis　process　for　conquering　traditional　obstacles　and　improving　therapeutic　efficiency　is　an　appealing,　yet　remarkably　challenging　task.　Herein,　a　universal　nanoplatform　allows　all　cancerous　cell-targeting,　acid-responsive,　cell　imaging,　synergistic　chemotherapy,　and　nucleolar　targeted　phototherapy　function　was　tactfully　designed　and　constructed　by　using　chemotherapeutic　agents　ursolic　acid　(UA),　sorafenib　(SF),　and　carbon　dots　(CDs)　photosensitizers　(PSs).　The　designed　US　NPs　were　formed　by　self-assembly　of　UA　and　SF　associated　with　electrostatic,　π-π　stacking,　and　hydrophobic　interactions.　After　hydrogen　bonding　reaction　with　CDs,　the　obtained　(denoted　as　USC　NPs)　have　a　relatively　uniform　size　of　an　average　125.6　nm,　which　facilitated　the　favorable　accumulation　of　drugs　at　the　tumor　region　through　a　potential　enhanced　permeability　and　retention　(EPR)　effect　as　compared　to　their　counterpart　of　free　CDs　solution.　Both　in　vitro　and　in　vivo　studies　revealed　that　the　advanced　platform　commenced　synergistic　anticancer　therapeutic　potency,　imperceptible　systematical　toxicity,　and　remarkable　reticence　towards　drug-resistant　cancer　cells.　Moreover,　the　CDs　PSs　possess　intrinsic　nucleolus-targeting　ability.　Taken　together,　this　theranostics　system　can　fully　play　the　role　of　＇killing　three　birds　with　one　stone＇　in　a　safe　manner,　implying　a　promising　direction　for　exploring　treatment　strategies　for　cancer　and　endowing　them　with　great　potential　for　future　translational　research　and　providing　a　new　vision　for　the　advancing　of　an　exceptionally　forceful　protocol　for　practical　cancer　therapy.　©　2022