Electron-transporting　materials　(ETMs)　with　higher　carrier　mobility　and　a　suitable　band　gap　structure　play　a　significant　role　in　determining　the　photovoltaic　performance　of　perovskite　solar　cells　(PSCs).　Herein,　cube-like　mesoporous　single-crystal　anatase　TiO2　(Meso-TiO2)　nanoparticles　synthesized　by　using　a　facile　hydrothermal　method　were　utilized　as　an　efficient　ETM　for　PSCs.　The　superior　semiconducting　properties　of　the　Meso-TiO2　based　ETM　enabled　the　best　power　conversion　efficiency　(PCE)　of　20.05%　for　a　PSC.　Moreover,　the　device　retained　80%　of　its　initial　PCE　after　being　stored　in　ambient　conditions　for　20　days　under　25　±　5%　relative　humidity.　In　contrast　to　the　commercial　TiO2　ETM,　the　Meso-TiO2　ETM　based　PSC　showed　a　distinguished　interface　with　better　interfacial　conditions　and　improved　carrier　extraction　originating　from　the　cube-like　mesoporous　single-crystal　anatase　TiO2　ETM.　©　2022　Elsevier　Inc.