As　an　emerging　two-dimensional　material,　MXenes　exhibit　enormous　potentials　in　the　fields　of　energy　storage　and　conversion,　due　to　their　superior　conductivity,　effective　surface　chemistry,　accordion-like　layered　structure,　and　numerous　ordered　nanochannels.　However,　interlayer　accumulation　and　chemical　sluggishness　of　structural　elements　have　hampered　the　demonstration　of　the　superiorities　of　MXenes.　By　metal　preintercalation　and　in　situ　electrochemical　oxidization　strategies　on　V2CTx,　MXene　has　enlarged　its　interplanar　spacing　and　excited　the　outermost　vanadium　atoms　to　achieve　frequent　transfer　and　high　storage　capacity　of　Zn　ions　in　aqueous　zinc-ion　batteries　(ZIBs).　Benefiting　from　the　synergistic　effects　of　these　strategies,　the　resulting　VOx/Mn–V2C　electrode　exhibits　the　high　capacity　of　530 mA　h　g−1　at　0.1　A　g−1,　together　with　a　remarkable　energy　density　of　415 W　h　kg−1　and　a　power　density　of　5500 W　kg−1.　Impressively,　the　electrode　delivers　excellent　cycling　stability　with　Coulombic　efficiency　of　nearly　100%　in　2000　cycles　at　5　A　g−1.　The　satisfactory　electrochemical　performances　bear　comparison　with　those　in　reported　vanadium-based　and　MXene-based　aqueous　ZIBs.　This　work　provides　a　new　methodology　for　safe　preparation　of　outstanding　vanadium-based　electrodes　and　extends　the　applications　of　MXenes　in　the　energy　storage　field.　©　2023　The　Authors.　Advanced　Science　published　by　Wiley-VCH　GmbH.