Currently,　covalent　organic　framework-based　(COF-based)　monolithic　columns　show　excellent　application　potential　for　high-efficient　sorbent　in　sample　preparation.　Hydrophobic　and　π-π　stacking　interaction　were　their　primary　adsorption　mechanisms　for　extraction.　Hydrophilic　interaction　has　not　been　involved　yet.　Herein,　a　novel　COF-based　monolithic　column　with　hydrophilic　interaction　and　π-π　stacking　interaction　has　been　fabricated　by　the　embedment　of　COFTAPB-TPA　microspheres　into　urea–formaldehyde　resin　(UF)　monolith.　Due　to　the　excellent　adhesion　performance　of　UF,　the　COFTAPB-TPA　microspheres　could　be　steadily　embedded　into　the　UF　monolith.　Taking　the　advantages　of　the　hydrophilic　interaction　and　the　π-π　stacking　interaction　between　the　COFTAPB-TPA@UF　monolith　and　synthetic　phenolic　antioxidants　(SPAs),　the　COFTAPB-TPA@UF　monolith　was　adopted　as　efficient　sorbent　for　in-tube　SPME　of　trace　SPAs　in　edible　oils.　Several　SPME　parameters,　including　the　percentage　of　ACN　in　the　sampling　solution　and　eluent,　the　collection　time　span,　and　the　pH　value　of　the　sampling　solution,　were　optimized　for　satisfactory　SPME　performance.　Under　the　optimized　conditions,　the　LODs　of　the　analytes　varied　from　0.2　to　1.2　ng/mL,　and　the　recoveries　ranged　from　78.1　%　to　98.4　%　for　sunflower　oil　samples　at　three　spiked　levels,　with　the　RSDs　lower　than　7.2　%,　indicating　the　superior　extraction　capacity　of　the　COFTAPB-TPA@UF　monolith　as　well　as　the　promising　feasibility　of　the　proposed　in-tube　SPME-HPLC　method.　This　work　lighted　a　facile　way　for　COF-based　monoliths　with　hydrophilic　interaction,　and　further　expanded　their　applications　for　sample　preparation.　©　2022　Elsevier　B.V.