The　migration　of　antibiotics　and　bacterial　communities　between　sediments　and　pore　water　occurring　in　the　lake,　which　is　affected　by　aquatic　vegetation.　However,　the　differences　in　bacterial　community　structure　and　biodiversity　between　pore　water　and　sediments　with　plants　in　lakes　under　antibiotic　stress　are　still　poorly　understood.　We　collected　pore　water　and　sediments　in　both　wild　and　cultivated　Phragmites　australis　regions　in　the　Zaozhadian　(ZZD)　Lake　to　explore　the　characteristics　of　the　bacterial　community.　Our　results　showed　that　the　diversity　of　bacterial　community　in　sediment　samples　were　significantly　higher　than　those　in　pore　water　samples　in　both　P.　australis　regions.　Due　to　higher　antibiotic　levels　in　sediments　from　the　cultivated　P.　australis　region,　the　composition　of　bacterial　communities　showed　a　difference,　which　reduced　the　relative　abundance　of　dominant　phyla　in　pore　water　and　increased　that　in　sediments.　The　higher　bacterial　variations　in　pore　water　could　be　explained　by　sediment　in　the　cultivated　P.　australis　region　than　that　in　wild　P.　australis　region,　therefore　plant　cultivation　might　change　the　source-sink　pattern　between　sediments　and　pore　water.　The　dominant　factors　shaping　the　bacterial　communities　in　the　wild　P.　australis　region　pore　water　or　sediment　were　NH4-N,　NO3-N,　and　particle　size,　while　cultivated　P.　australis　region　pore　water　or　sediment　were　oxytetracycline,　tetracycline,　etc.　The　findings　of　this　work　indicates　that　the　antibiotic　pollution　caused　by　planting　activities　has　a　greater　impact　on　the　bacterial　community,　which　will　provide　a　reference　for　the　use　and　management　of　antibiotics　in　lake　ecosystems.　Copyright　©　2023　Zhang,　Bai,　Zhai,　Zhang,　Wei,　Wang,　Liu,　Xiao　and　Jorquera.