To　study　the　distribution　laws　of　hot-spot　stress,　fatigue　performance　evolution,　and　fatigue　failure　mode　of　the　composite　girder　with　corrugated　steel　webs-concrete　filled　steel　tubular　(CSW-CFST)　truss　chords,　the　fatigue　performance　test　and　finite　element　analysis　on　the　composite　girder　with　CSW-CFST　truss　chords　and　the　composite　girder　with　corrugated　steel　webs-steel　tubular　(CSW-ST)　truss　chords　were　carried　out　separately.　The　differences　and　similarites　between　the　fatigue　performance　between　composite　girders　with　CSW-CFST　truss　chords　and　CSW-ST　truss　chords　were　explored.　The　essential　reason　for　the　improved　fatigue　performance　of　the　composite　girder　with　concrete-filled　chords　was　analyzed,　and　the　evaluation　method　for　the　fatigue　life　of　the　composite　girder　with　CSW-CFST　truss　chords　was　discussed.　Moreover,　the　test　result　was　compared　with　the　calculated　fatigue　life　for　the　composite　girder　with　CSW-CFST　truss　chords　according　to　the　design　standards　of　the　American　Petroleum　Institute　(API),　Comité　International　pour　le　Développement　et　l＇Etude　de　la　Construction　Tubulaire　(CIDECT),　and　Det　Norske　Veritas　(DNV)　separately.　Research　results　show　that　the　hot-spot　stress　of　the　composite　girder　with　CSW-CFST　truss　chords　acquired　by　the　linear　extrapolation　is　1.036　times　that　acquired　by　the　quadratic　extrapolation.　Therefore,　For　safety,　the　hot-spot　stress　of　the　composite　girder　with　CSW-CFST　truss　chords　shall　be　acquired　by　the　linear　extrapolation.　The　hot-spot　stress　is　significantly　larger　in　the　inclined　web　segment　than　that　in　the　straight　web　segment,　and　the　maximum　hot-spot　stress　is　distributed　near　the　intersection　of　the　inclined　web　and　the　arc　transition　segment.　Compared　with　the　situation　of　the　composite　girder　with　CSW-ST　truss　chords,　the　hot-spot　stress　of　the　composite　girder　with　CSW-CFST　truss　chords　can　be　reduced　by　26.8%　by　concrete-filled　chords,　but　the　distribution　laws　of　hot-spot　stress　remain　changed.　It　is　recommended　that　the　repeated　loading　times　at　the　initial　moment　of　the　fatigue　crack　should　be　defined　as　the　fatigue　life　of　the　composite　girder　with　CSW-CFST　truss　chords.　The　concrete-filled　chords　can　delay　the　fatigue　crack　propagation　rate　along　the　directions　of　the　thickness　and　length　of　chords,　and　can　improve　the　fatigue　life　of　the　composite　girder　with　CSW-CFST　truss　chords　by　61.5%,　with　the　fatigue　failure　mode　and　fatigue　crack　type　of　the　composite　girder　unchanged.　The　minimum　difference　between　the　test　result　and　the　calculated　fatigue　life　of　the　composite　girder　with　CSW-CFST　truss　chords　by　DNV　is　achieved,　which　is　less　than　26.4%.　Thus,　it　is　recommended　that　the　fatigue　design　stress　(S)-fatigue　life　(N)　curve　of　steel　tubular　intersecting　joints　provided　by　DNV　should　be　adopted　to　preliminarily　calculate　the　fatigue　life　of　the　composite　girder　with　CSW-CFST　truss　chords.　©　2022　Chang＇an　University.　All　rights　reserved.