Although　the　tetrapyrrolic　macrocycle　system　provides　a　promising　platform　for　building　molecular　devices,　investigating　the　relationship　between　the　conductance　and　the　substituents　is　still　a　challenge.　Here,　three　A2B　type　corroles　with　the　substituents　exhibiting　electron-withdrawing　and　electron-donating　effects　on　B-site　are　prepared.　The　single-molecule　conductance　results　via　the　scanning　tunneling　microscope　break　junction　(STM-BJ)　technique　demonstrate　that　the　single-molecule　conductance　of　corroles　is　suppressed　by　the　electron-withdrawing　substituent　while　it　is　enhanced　by　the　electron-donating　substituent,　which　is　attributed　to　the　change　of　the　energy　gap　between　the　HOMO　and　LUMO.　©　2022　American　Chemical　Society.