Anisotropically　conductive　hydrogels　have　promising　applications　in　artificial　intelligence　and　wearable　flexible　electronics.　However,　for　conductive　hydrogels,　the　integration　of　comprehensive　properties,　such　as　high　electrical　conductivity,　strong　moisture　retention,　and　high　mechanical　properties,　is　very　important.　In　this　article,　sandwich-shaped　anisotropically　conductive　hydrogels　were　constructed　with　a　conductivity　of　up　to　1.5　S/m.　The　difference　in　conductivity　along　the　different　directions　is　about　a　factor　of　6.　The　formation　of　dynamic　coordination　bonding　enhances　the　cross-linked　network　between　poly(acrylic　acid)　and　Nd3+,　which　causes　the　hydrogels　to　have　excellent　self-healing　properties　and　fatigue　resistance,　with　a　self-healing　efficiency　of　up　to　90%.　The　middle　layer　of　the　hydrogels　is　compounded　with　nanographene,　which　cuases　the　hydrogels　to　have　good　mechanical　properties,　such　as　ultrastretchability　(∼1930%)　and　high　strength　(∼0.7　MPa).　The　binary　solvent　consisting　of　glycerin　and　water　gives　the　hydrogels　an　excellent　moisturizing　and　antifreezing　function.　It　maintains　good　flexibility　and　conductivity　even　at　−18　°C.　Based　on　the　rapid　response　and　high　sensitivity,　the　sandwich-shaped　hydrogel　strain　sensors　can　detect　human　motion　(such　as　knuckle　motion,　wrist　movement,　etc.),　showing　great　application　potential　in　flexible　sensors.　©　2023　American　Chemical　Society.