Synthesis, structure–activity relationship, and biological evaluation of quinolines for development of anticancer agents - Details

author：

Indexed by：

Scopus

Abstract：

Tetrahydro-β-carbolines　(THβCs)　are　a　kind　of　natural　alkaloids　with　multiple　pharmaceutical　activities.　Herein,　a　focused　compound　library　derived　from　THβCs　was　synthesized　and　their　anticancer　activities　were　studied　in　several　cancer　cell　lines.　Among　them,　three　compounds　showed　considerable　anticancer　activities　with　low　micromolar　to　submicromolar　IC50　values.　The　abilities　to　induce　apoptosis　and　alter　mitochondrial　membrane　potential　levels,　which　are　comparable　to　those　of　the　commercial　anticancer　drug　adriamycin,　were　confirmed　by　one　representative　compound　(21)　on　the　B16/F10　cell　line.　Our　preliminary　structure–activity　relationship　studies　indicated　that　alkylamines　with　suitable　lengths　are　very　important　for　potency　improvement.　©　2023　Deutsche　Pharmazeutische　Gesellschaft.

Keyword：

anticancer quinolines SAR tetrahydro-β-carbolines

Community：

[ 1 ] [Li X.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 2 ] [Ye F.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 3 ] [Wang Y.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 4 ] [Sun X.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 5 ] [Chen H.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 6 ] [Chen T.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 7 ] [Gao Y.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China
[ 8 ] [Chen H.]Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fujian, Fuzhou, China

Reprint 's Address：

Email：

Show more details

Related Keywords：

Synthesis, structure-activity relationship, and biological evaluation of quinolines for development of anticancer agents
2023，ARCHIV DER PHARMAZIE
Cu-Catalyzed Aerobic Oxidative Coupling of Tetrahydro-beta-carbolines with Indoles
2021，CHEMISTRYSELECT
Synthesis, Anticancer Activity, and Molecular Docking of New 1,2,3-Triazole Linked Tetrahydrocurcumin Derivatives
2024，MOLECULES
Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants
2018，CURRENT MEDICINAL CHEMISTRY
Antifungal Proteins with Antiproliferative Activity on Cancer Cells and HIV-1 Enzyme Inhibitory Activity from Medicinal Plants and Medicinal Fungi
2019，CURRENT PROTEIN & PEPTIDE SCIENCE

Source ：

Archiv der Pharmazie

ISSN： 0365-6233

Year： 2023

Issue： 7

Volume： 356

4 . 3

JCR@2023

4 . 3 0 0

JCR@2023

ESI HC Threshold：26

JCR Journal Grade：1

CAS Journal Grade：2

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 2

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 4

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search SCOPUS

Type
Departments

All Years Choose Year From to