Although　zinc-based　batteries　are　promising　candidates　for　eco-friendly　and　cost-effective　energy　storage　devices,　their　performance　is　severely　retarded　by　dendrite　formation.　As　the　simplest　zinc　compounds,　zinc　chalcogenides,　and　halides　are　individually　applied　as　a　Zn　protection　layer　due　to　high　zinc　ion　conductivity.　However,　the　mixed-anion　compounds　are　not　studied,　which　constrains　the　Zn2+　diffusion　in　single-anion　lattices　to　their　own　limits.　A　heteroanionic　zinc　ion　conductor　(ZnyO1−xFx)　coating　layer　is　designed　by　in　situ　growth　method　with　tunable　F　content　and　thickness.　Strengthened　by　F　aliovalent　doping,　the　Zn2+　conductivity　is　enhanced　within　the　wurtzite　motif　for　rapid　lattice　Zn　migration.　ZnyO1−xFx　also　affords　zincophilic　sites　for　oriented　superficial　Zn　plating　to　suppress　dendrite　growth.　Therefore,　ZnyO1−xFx-coated　anode　exhibits　a　low　overpotential　of　20.4 mV　for　1000 h　cycle　life　at　a　plating　capacity　of　1.0 mA h cm−2　during　symmetrical　cell　test.　The　MnO2//Zn　full　battery　further　proves　high　stability　of　169.7　mA h g−1　for　1000　cycles.　This　work　may　enlighten　the　mixed-anion　tuning　for　high-performance　Zn-based　energy　storage　devices.　©　2023　Wiley-VCH　GmbH.