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Abstract:
A novel difluorocarbene promoted single-atom skeletal editing of 2H-indazoles is demonstrated herein. Ethyl bromodifluoroacetate was severed as the difluorocarbene source in the current protocol, facilitating the cleavage of the N-N bond via carbon atom insertion. This metal-free ring expansion reaction enables the late-stage diversification of indazole skeletons, assembling a diverse array of functionalized quinazolin-4(3H)-ones in decent yields with excellent functional group compatibility.
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SCIENCE CHINA-CHEMISTRY
ISSN: 1674-7291
CN: 11-5839/O6
Year: 2023
Issue: 7
Volume: 66
Page: 1975-1981
1 0 . 4
JCR@2023
1 0 . 4 0 0
JCR@2023
ESI HC Threshold:39
JCR Journal Grade:1
CAS Journal Grade:2
Cited Count:
WoS CC Cited Count: 26
SCOPUS Cited Count: 27
ESI Highly Cited Papers on the List: 0 Unfold All
WanFang Cited Count:
Chinese Cited Count:
30 Days PV: 0
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