Metal-organic　frameworks　(MOFs)　are　new　porous　materials　composed　of　metal　centers　and　organic　ligand　bridges,　which　received　great　attention　in　the　field　of　photocatalysis.　In　this　work,　Ag2CrO4@MIL-125(Ti)-NH2　(denoted　as　AgCr@M125)　Z-scheme　heterojunctions　were　synthesized　via　a　simple　microemulsion　method,　by　which　highly　dispersed　nano-sized　Ag2CrO4　can　be　anchored　uniformly　on　the　surfaces　of　porous　MIL-125(Ti)-NH2　(denoted　as　M125).　Compared　with　pure　M125　and　Ag2CrO4,　the　as-prepared　AgCr@M125　hybrids　show　significant　photocatalytic　efficiency　against　inactivated　Staphylococcus　aureus　(S.　aureus),　reaching　over　97%　inactivation　of　the　bacteria　after　15　min　of　visible　light　irradiation.　Notably,　the　photocatalytic　activity　of　the　obtained　20%AgCr@M125　is　about　1.75　times　higher　than　that　of　AgCr-M125,　which　was　prepared　via　a　traditional　precipitation　method.　The　enhanced　photocatalytic　antibacterial　activity　of　the　AgCr@M125　photocatalytic　system　is　strongly　ascribed　to　a　direct　Z-scheme　mechanism,　which　can　be　carefully　discussed　based　on　energy　band　positions　and　time-dependent　electron　spin　response　(ESR)　experiments.　Our　work　highlights　a　simple　way　to　enhance　the　antibacterial　effect　by　coupling　with　Ag2CrO4　and　M125　via　a　microemulsion-assisted　strategy　and　affords　an　ideal　example　for　developing　MOFs-based　Z-scheme　photocatalysts　with　excellent　photoactivity.