Effects of trichlorfon on the contents of acetylcholine and choline in fish brain microdialysis samples by UPLC-MS/MS method - Details

author：

Xia, Qian (Xia, Qian.) ^[1] | Li, Huichen (Li, Huichen.) ^[2] | Chen, Jinfeng (Chen, Jinfeng.) ^[3] | He, Yu (He, Yu.) ^[4] (Scholars：何聿) | Lin, Zhenyu (Lin, Zhenyu.) ^[5] (Scholars：林振宇)

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Abstract：

A　combination　of　microdialysis　sampling　with　ultra-high　performance　liquid　chromatography-tandem　mass　spectrometryUPLC-MS/MSwas　used　to　quantitatively　analyze　the　effects　of　organophosphorus　pesticides　trichlorfon　on　acetylcholine　ACh　and　choline　Ch　in　the　brain　of　crucian　carp.　The　mechanism　of　organophosphorus　pesticides　poisoning　was　preliminarily　discussedshowing　that　the　ACh　content　in　the　brain　of　fish　increased　significantly　with　the　increase　of　the　exposure　time　to　trichlorfonwhile　the　Ch　content　decreased.　It　indicated　that　organophosphorus　pesticides　inhibited　the　activity　of　cholinesterase　in　organisms.　©　2023,　Youke　Publishing　Co.,Ltd.　All　rights　reserved.

Keyword：

Dialysis Fish High performance liquid chromatography Mass spectrometry Pesticides

Community：

[ 1 ] [Xia, Qian]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou; 350116, China
[ 2 ] [Li, Huichen]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou; 350116, China
[ 3 ] [Chen, Jinfeng]China Certification & In spection Group Fujian CoLtd., Fuzhou; 350116, China
[ 4 ] [He, Yu]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou; 350116, China
[ 5 ] [Lin, Zhenyu]Key Laboratory for Analytical Science of Food Safety and Biology, Ministry of Education, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou; 350116, China

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Source ：

Chinese Journal of Analysis Laboratory

ISSN： 1000-0720

CN： 11-2017/TF

Year： 2023

Issue： 4

Volume： 42

Page： 442-448

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ESI Highly Cited Papers on the List： 0 Unfold All

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30 Days PV： 3

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